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. 2001 Apr;107(4):E48.
doi: 10.1542/peds.107.4.e48.

High levels of interferon gamma in the plasma of children with complete interferon gamma receptor deficiency

C Fieschi  1 , S Dupuis, C Picard, C I Smith, S M Holland, J L Casanova
Affiliations

High levels of interferon gamma in the plasma of children with complete interferon gamma receptor deficiency

C Fieschi et al. Pediatrics. 2001 Apr.

Abstract

We have found that children with complete interferon gamma (IFNgamma) receptor deficiency, unlike patients with other genetic defects predisposing them to mycobacterial diseases, have very high levels of IFNgamma in their plasma. This unexpected observation provides a simple and accurate diagnostic method for complete IFNgamma receptor deficiency in children with clinical disease caused by bacille Calmette-Guérin vaccines or environmental nontuberculous mycobacteria.

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