Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1999 Mar-Apr;1(3):94-7.
doi: 10.1097/00125817-199903000-00006.

Detection of mosaicism in amniotic fluid cultures: a CYTO2000 collaborative study

P S Ing  1 , D L Van Dyke, S P Caudill, J A Reidy, G Bice, F R Bieber, P D Buchanan, A J Carroll, S W Cheung, G DeWald, R P Donahue, H A Gardner, J Higgins, L Y Hsu, M Jamehdor, E A Keitges, C H Laundon, F W Luthardt, J Mascarello, K M May, J M Meck, C Morton, S Patil, D Peakman, M J Pettenati, N Rao, W G Sanger, D F Saxe, S Schwartz, G S Sekhon, G H Vance, H E Wyandt, C W Yu, J Zenger-Hain, A T Chen
Affiliations
Free article
Comparative Study

Detection of mosaicism in amniotic fluid cultures: a CYTO2000 collaborative study

P S Ing et al. Genet Med. 1999 Mar-Apr.
Free article

Abstract

Purpose: To evaluate the assumptions on which the American College of Medical Genetics (ACMG) Standards and Guidelines for detecting mosaicism in amniotic fluid cultures are based.

Methods: Data from 653 cases of amniotic fluid mosaicism were collected from 26 laboratories. A chi-square goodness-of-fit test was used to compare the observed number of mosaic cases with the expected number based on binomial distribution theory.

Results: Comparison of observed data from the in situ colony cases with the expected distribution of cases detected based on the binomial distribution did not reveal a significant difference (P = 0.525).

Conclusions: The empirical data fit the binomial distribution. Therefore, binomial theory can be used as an initial discussion point for determining whether ACMG Standards and Guidelines are adequate for detecting mosaicism.

PubMed Disclaimer

Publication types