Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001 May;22(5):795-801.
doi: 10.1016/s0196-9781(01)00393-x.

The regulation of human corticotrophin-releasing hormone gene expression in the placenta

B R King  1 , R Smith, R C Nicholson
Affiliations
Review

The regulation of human corticotrophin-releasing hormone gene expression in the placenta

B R King et al. Peptides. 2001 May.

Corrected and republished in

Abstract

Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide that is expressed in the hypothalamus and the human placenta. Placental CRH production has been linked to the determination of gestational length in the human. Although encoded by a single copy gene, CRH expression in the placenta is regulated differently to the hypothalamus. Glucocorticoids stimulate CRH promoter activity in the placenta but inhibit it's activity in the hypothalamus, via mechanisms involving different regions of the CRH promoter. We discuss how various stimuli alter CRH promoter activity and why these responses are unique to the placenta.

PubMed Disclaimer

LinkOut - more resources