HERG K+ channels: friend and foe
- PMID: 11339975
- DOI: 10.1016/s0165-6147(00)01662-x
HERG K+ channels: friend and foe
Erratum in
- Trends Pharmacol Sci 2001 Aug;22(8):438
Abstract
The K+ channel encoded by the human ether-à-go-go related gene (HERG) is one of many ion channels that are crucial for normal action potential repolarization in cardiac myocytes. HERG encodes the pore-forming subunit of the rapid component of the delayed rectifier K+ channel, I(K(Vr)). HERG K+ channels are of considerable pharmaceutical interest as possible therapeutic targets for anti-arrhythmic agents and as the molecular target responsible for the cardiac toxicity of a wide range of pharmaceutical agents. Recent studies of the molecular basis of the promiscuity of HERG K+ channel drug binding has not only started to shed light on this tricky pharmaceutical problem but has also provided further insights into the structure and function of HERG K+ channels.
Similar articles
-
Molecular determinants of dofetilide block of HERG K+ channels.Circ Res. 1998 Feb 23;82(3):386-95. doi: 10.1161/01.res.82.3.386. Circ Res. 1998. PMID: 9486667
-
I(Kr): the hERG channel.J Mol Cell Cardiol. 2001 May;33(5):835-49. doi: 10.1006/jmcc.2000.1317. J Mol Cell Cardiol. 2001. PMID: 11343409 Review.
-
Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241.FEBS Lett. 1997 Sep 8;414(2):435-8. doi: 10.1016/s0014-5793(97)01030-2. FEBS Lett. 1997. PMID: 9315735
-
Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes.Am J Physiol. 1997 Mar;272(3 Pt 2):H1309-14. doi: 10.1152/ajpheart.1997.272.3.H1309. Am J Physiol. 1997. PMID: 9087606
-
Structural determinants and biophysical properties of HERG and KCNQ1 channel gating.J Mol Cell Cardiol. 2003 Jan;35(1):27-35. doi: 10.1016/s0022-2828(02)00286-9. J Mol Cell Cardiol. 2003. PMID: 12623297 Review.
Cited by
-
Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue.Pharmaceuticals (Basel). 2023 Aug 24;16(9):1204. doi: 10.3390/ph16091204. Pharmaceuticals (Basel). 2023. PMID: 37765012 Free PMC article.
-
A novel genetic modifier for clarithromycin-related cardiac arrhythmia risk?Ther Adv Infect Dis. 2014 Apr;2(2):71-2. doi: 10.1177/2049936114522996. Ther Adv Infect Dis. 2014. PMID: 25165557 Free PMC article. No abstract available.
-
The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics.Eur Biophys J. 2004 Apr;33(2):89-97. doi: 10.1007/s00249-003-0338-3. Epub 2003 Sep 10. Eur Biophys J. 2004. PMID: 13680209 Review.
-
KCNH3 Loss-of-Function Variant Associated with Epilepsy and Neurodevelopmental Delay Enhances Kv12.2 Channel Inactivation.Int J Mol Sci. 2025 May 13;26(10):4631. doi: 10.3390/ijms26104631. Int J Mol Sci. 2025. PMID: 40429775 Free PMC article.
-
Pathogenic KCNH2 variant in monozygotic twins with speech delay and lower risk type 2 long QT syndrome.Neurogenetics. 2025 Aug 15;26(1):63. doi: 10.1007/s10048-025-00842-7. Neurogenetics. 2025. PMID: 40815429
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources