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Review
. 2001 May;107(9):1055-61.
doi: 10.1172/JCI12980.

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

D T Denhardt  1 , M Noda, A W O'Regan, D Pavlin, J S Berman
Affiliations
Review

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

D T Denhardt et al. J Clin Invest. 2001 May.
No abstract available

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Figures

Figure 1
Figure 1
Some features of the OPN protein. Indicated sites of O-glycosylation and phosphorylation are intended to be representative; both vary (phosphorylation in particular) with the source of the protein. Numbering of the amino acids is based on the human protein, and the signal sequence is not illustrated.
Figure 2
Figure 2
Pro- and anti-inflammatory actions of OPN in cell injury and infection. The left side of the diagram summarizes proinflammatory and anti-inflammatory events believed to be regulated by OPN. The right side summarizes known or predicted events in the OPN-null mouse. The center illustrates the wounding of the epithelium or endothelium, which is followed by macrophage-mediated containment of an infecting agent and, finally, repair of the injury. MMP-2, matrix metalloproteinase 2; M, macrophage. See text for further details.
Figure 3
Figure 3
OPN mRNA expression during tooth relocation as assessed by in situ hybridization with an OPN mRNA probe in sections of a mouse dentoalveolar complex. (a) A control, untreated site. The tooth was moved for 3 days by a controlled orthodontic force, resulting in bone formation in distal periodontal sites (b) and direct resorption in mesial sites (c) of the first molar. Following relocation, the OPN mRNA hybridization signal decreased in periodontal osteoblasts in bone formation sites (b, right side), and increased in cells (osteoblasts, osteoclasts, and their precursors) lining alveolar bone surface in resorption sites (c). The mechanically induced OPN hybridization signal is present in alveolar osteocytes within the bone adjacent to both resorption and formation sites (b, c). A control sense OPN probe did not yield any signal above background. F, direction of orthodontic force and tooth movement; TR, tooth root; PD, periodontium; AB, alveolar bone; OB, osteoblasts; OCY, osteocytes; CBL, cementoblasts; OCL and MN, osteoclasts and their mononuclear precursors. Note that the PD is enlarged in b, where the TR is being pulled away from the AB, but that it is reduced in c, where the PD is being compressed between the TR and the AB.
See this image and copyright information in PMC

References

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