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Review
. 2001 Jun;13(3):290-301.
doi: 10.1016/s0955-0674(00)00211-8.

Spliceosomal UsnRNP biogenesis, structure and function

C L Will  1 , R Lührmann
Affiliations
Review

Spliceosomal UsnRNP biogenesis, structure and function

C L Will et al. Curr Opin Cell Biol. 2001 Jun.

Abstract

Significant advances have been made in elucidating the biogenesis pathway and three-dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6*U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre-mRNA splicing has been presented.

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