Review
doi: 10.1016/s0955-0674(00)00211-8.
Spliceosomal UsnRNP biogenesis, structure and function
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- PMID: 11343899
- DOI: 10.1016/s0955-0674(00)00211-8
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Review
Spliceosomal UsnRNP biogenesis, structure and function
Curr Opin Cell Biol.
2001 Jun.
Abstract
Significant advances have been made in elucidating the biogenesis pathway and three-dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6*U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre-mRNA splicing has been presented.
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