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Review
. 2001 Jun;13(3):332-7.
doi: 10.1016/s0955-0674(00)00216-7.

Regulation and function of the p53 tumor suppressor protein

K M Ryan  1 , A C Phillips, K H Vousden
Affiliations
Review

Regulation and function of the p53 tumor suppressor protein

K M Ryan et al. Curr Opin Cell Biol. 2001 Jun.

Abstract

Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.

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