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Review
. 2001 May;26(5):291-7.
doi: 10.1016/s0968-0004(01)01804-7.

Signaling at zero G: G-protein-independent functions for 7-TM receptors

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Review

Signaling at zero G: G-protein-independent functions for 7-TM receptors

J A Brzostowski et al. Trends Biochem Sci. 2001 May.

Abstract

Eukaryotic cells, whether free-living, single-celled microbes or components of complex metazoa, can sense environmental cues through specialized seven-transmembrane (7-TM) receptors (also called heptahelical or G-protein-coupled receptors). 7-TM receptors detect "inputs" such as light, peptide hormones, neurotransmitters, pheromones, odorants, morphogens and chemoattractants, linking extracellular stimuli to intracellular signaling networks via heterotrimeric G proteins. Recently, this obligatory paradigm has been challenged. A growing body of evidence indicates that 7-TM receptors can also transmit extracellular signals through mechanisms that function independently of G-protein coupling. This review discusses pathways and protein interactions for 7-TM receptors signaling "at zero G" in Dictyostelium and mammalian cells.

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Comment in

  • Signaling at zero G: a comment.
    Galve-Roperh I, Sánchez C, Guzmán M. Galve-Roperh I, et al. Trends Biochem Sci. 2001 Sep;26(9):533. doi: 10.1016/s0968-0004(01)01922-3. Trends Biochem Sci. 2001. PMID: 11570375 No abstract available.

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