Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2001 May 8;98(10):5379-81.
doi: 10.1073/pnas.101137698.

Don't stop for repairs in a war zone: Darwinian evolution unites genes and environment in cancer development

J Breivik  1
Affiliations
Comment

Don't stop for repairs in a war zone: Darwinian evolution unites genes and environment in cancer development

J Breivik. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
The cell cycle Grand Prix and effects of opposing repair strategies in different environments. Team I (green) always stops for repairs when a problem is indicated, whereas team II (red) ignores all warning lights. Team I wins under ordinary conditions (A) because it always has a faultless vehicle, whereas team II accumulates errors. In the harsher environment (B) the vehicles accumulate damages more quickly than can be repaired, and team I gets trapped in the checkpoint. Team II, on the other hand, jerks along in its faulty vehicle with a fair chance of making the finish line. This simple assessment of repair strategies thereby provides an explanation for the paradox that mutagenic environments favor repair deficiency.
Figure 2
Figure 2
Mutagenic selection of genetic instability. Bardelli et al. (3) started out with the genetically stable cell line H3 (HCT 116 artificially complemented with chromosome 3). This cell line was first exposed to selection pressure involving cytotoxic levels of PhIP. The selected cells expressed CIN, illustrated as a trisomy and a translocation. The same cell line (H3) then was exposed to selection pressure involving cytotoxic levels of MNNG (N-methyl-N′-nitro-N-nitrosoguanine). This time the selected cells expressed MIN, illustrated as slippage in a repetitive sequence. The experiment thus supports the hypothesis that the CIN and MIN phenotypes reflect Darwinian adaptations to different mutagenic environments, methylating and BAF agents, respectively.
See this image and copyright information in PMC

Comment on

  • Carcinogen-specific induction of genetic instability.
    Bardelli A, Cahill DP, Lederer G, Speicher MR, Kinzler KW, Vogelstein B, Lengauer C. Bardelli A, et al. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5770-5. doi: 10.1073/pnas.081082898. Epub 2001 Apr 10. Proc Natl Acad Sci U S A. 2001. PMID: 11296254 Free PMC article.

References

    1. Klein G. Adv Cancer Res. 1998;72:1–23. - PubMed
    1. Breivik J, Gaudernack G. Semin Cancer Biol. 1999;9:245–254. - PubMed
    1. Bardelli A, Cahill D P, Lederer G, Speicher M R, Kinzler K W, Vogelstein B, Lengauer C. Proc Natl Acad Sci USA. 2001;98:5770–5775. . (First Published April 10, 2001; 10.1073/pnas.081082898) - PMC - PubMed
    1. Lengauer C, Kinzler K W, Vogelstein B. Nature (London) 1998;396:643–649. - PubMed
    1. Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed J C, Perucho M. Science. 1997;275:967–969. - PubMed

Publication types

LinkOut - more resources