Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Feb;53(2):652-5.
doi: 10.1172/JCI107600.

Augmentation of prolactin secretion by estrogen in hypogonadal women

S S Yen  1 , Y Ehara, T M Siler
Affiliations

Augmentation of prolactin secretion by estrogen in hypogonadal women

S S Yen et al. J Clin Invest. 1974 Feb.

Abstract

The effect of estrogen on prolactin (PRL) release and gonadotropin suppression was assessed in six experiments performed on four hypogonadal women. Ethinyl estradiol at a dose of 1 microgram/kg per day induced a significant elevation of serum PRL levels within the 1st wk of treatment. There was a further rise until a plateau was reached in about 3-4 wk to levels of more than 3 times the initial concentration. This was accompanied by a pattern of increased episodic fluctuation. The corresponding serum luteinizing hormone and follicle-stimulating hormone fell progressively during the study period. These data indicate that a positive feedback relationship between estrogen and PRL release exists in humans.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Neuroendocrinology. 1972;9(5):304-15 - PubMed
    1. Science. 1972 Sep 29;177(4055):1205-7 - PubMed
    1. J Clin Endocrinol Metab. 1972 Dec;35(6):897-904 - PubMed
    1. J Clin Endocrinol Metab. 1973 Mar;36(3):509-16 - PubMed
    1. Recent Prog Horm Res. 1972;28:471-526 - PubMed

Publication types