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Review
. 2001 Apr;73(3):271-7.
doi: 10.1007/BF02981951.

Role of Jak kinases and STATs in cytokine signal transduction

W J Leonard  1
Affiliations
Review

Role of Jak kinases and STATs in cytokine signal transduction

W J Leonard. Int J Hematol. 2001 Apr.

Abstract

The Janus family tyrosine kinase-signal transducer and activator of transcription (Jak-STAT) signaling pathway is broadly used by interferons and type I cytokines. These cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are cytosolic proteins; after activation, however, they are translocated to the nucleus where they function as transcription factors. This review summarizes salient features of the Jak-STAT pathway and focuses on the functional role of the different Jak kinases and STATs in vivo.

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