Review
doi: 10.1247/csf.26.19.
Role of ETS family transcription factors in vascular development and angiogenesis
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- PMID: 11345500
- DOI: 10.1247/csf.26.19
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Review
Role of ETS family transcription factors in vascular development and angiogenesis
Cell Struct Funct.
2001 Feb.
Free article
Abstract
The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif. This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors. This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis.
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