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Review
. 2001 Jun;69(6):3523-35.
doi: 10.1128/IAI.69.6.3523-3535.2001.

Type II secretion and pathogenesis

M Sandkvist  1
Affiliations
Review

Type II secretion and pathogenesis

M Sandkvist. Infect Immun. 2001 Jun.
No abstract available

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Figures

FIG. 1
FIG. 1
Alignment of genes encoding type II secretion pathways. Individual species with the names of their secretion genes and a schematic representation of the genes A to O and S shown as boxes with arrowheads to indicate their orientation. The designations of the xcp genes of P. aeruginosa and P. putida differ from those of other species. Spaces are introduced to indicate that genes are not adjacent. Lines connecting genes indicate that they are linked but interspersed by opposing promoters or other genes. The names of the O genes are vcpD (pilD) in V. cholerae, tapD in A. hydrophila, xcpA (pilD) in P. aeruginosa, and pilD in L. pneumophila. The gene alignment was done using previously published sequences (, , , , , , –34, 40, 44, 49, 59, 61, 66, 67, 82, 89, 129, 137, 140, 144). Sequences of open reading frames from S. putrefaciens, C. crescentus, Y. pestis, and G. sulfurreducens were obtained from The Institute for Genomic Research and Sanger Centre via the NCBI microbial genome database.
FIG. 2
FIG. 2
Regulation of secretion. Three steps in the colonization of a general surface, such as the surface of plant leaves, the mucosal epithelium, or a solid surface in an aquatic milieu. Secretion of virulence factors occurs only when the bacteria have reached a critical concentration or retrieved the appropriate signal from the surface.
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