Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 May;73(1):111-3.
doi: 10.1006/mgme.2001.3171.

Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms

X Yang  1 , R E Pratley, L J Baier, Y Horikawa, G I Bell, C Bogardus, P A Permana
Affiliations

Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms

X Yang et al. Mol Genet Metab. 2001 May.

Abstract

The DNA polymorphism SNP-43 in the calpain-10 gene is associated with insulin resistance and reduced skeletal muscle transcript in Pima Indians. Alternative splicing generates transcript isoforms calpain-10a to -10h. We determined the contribution of calpain-10 mRNA isoforms to the decreased total skeletal muscle calpain-10 mRNA levels observed in the G/G homozygotes. The expression levels of the major isoforms, calpain-10a and -10f, were positively correlated with the total calpain-10 mRNA levels, indicating a cumulative effect.

PubMed Disclaimer

LinkOut - more resources