Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Jun;45(6):1872-5.
doi: 10.1128/AAC.45.6.1872-1875.2001.

Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice

P Escobar  1 , V Yardley, S L Croft
Affiliations

Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice

P Escobar et al. Antimicrob Agents Chemother. 2001 Jun.

Abstract

In both scid and BALB/c mouse-Leishmania donovani models, hexadecyphosphocholine (miltefosine) and AmBisome had similar levels of activity. In contrast, sodium stibogluconate (Pentostam) was significantly less active against L. donovani in scid mice than in BALB/c mice. The in vitro anti-leishmanial activity of miltefosine was similar in peritoneal macrophages derived from both scid and BALB/c mice, whereas Pentostam and AmBisome were significantly more active in the latter.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Effects of HPC (A), sodium stibogluconate (B), and AmBisome (C) against L. donovani amastigotes in the livers of BALB/c and scid mice.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Alvar J, Canavate C, Gutierrez-Solar B, Jimenez M, Laguna F, Lopez-Velez R, Molina R, Moreno J. Leishmania and human immunodeficiency virus coinfection: the first 10 years. Clin Microbiol Rev. 1997;10:298–319. - PMC - PubMed
    1. Arthur G, Bittman R. The inhibition of cell signaling pathways by antitumor ether lipids. Biochim Biophys Acta. 1998;1390:85–102. - PubMed
    1. Berman J D. Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years. Clin Infect Dis. 1997;24:684–703. - PubMed
    1. Bosma G C, Custer R P, Bosma M J. A severe combined immunodeficiency mutation in the mouse. Nature. 1983;301:527–530. - PubMed
    1. Breiser A, Kim D J, Fleer E A, Damenz W, Drube A, Berger M, Nagel G A, Eibl H, Unger C. Distribution and metabolism of hexadecylphosphocholine in mice. Lipids. 1987;22:925–926. - PubMed

Publication types

MeSH terms

LinkOut - more resources