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. 2001 Jun;45(6):1872-5.
doi: 10.1128/AAC.45.6.1872-1875.2001.

Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice

P Escobar  1 , V Yardley, S L Croft
Affiliations

Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice

P Escobar et al. Antimicrob Agents Chemother. 2001 Jun.

Abstract

In both scid and BALB/c mouse-Leishmania donovani models, hexadecyphosphocholine (miltefosine) and AmBisome had similar levels of activity. In contrast, sodium stibogluconate (Pentostam) was significantly less active against L. donovani in scid mice than in BALB/c mice. The in vitro anti-leishmanial activity of miltefosine was similar in peritoneal macrophages derived from both scid and BALB/c mice, whereas Pentostam and AmBisome were significantly more active in the latter.

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Figures

FIG. 1
FIG. 1
Effects of HPC (A), sodium stibogluconate (B), and AmBisome (C) against L. donovani amastigotes in the livers of BALB/c and scid mice.
See this image and copyright information in PMC

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