Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 May 7;11(9):1225-7.
doi: 10.1016/s0960-894x(01)00188-3.

Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis

P J Brown  1 , L W Stuart, K P Hurley, M C Lewis, D A Winegar, J G Wilson, W O Wilkison, O R Ittoop, T M Willson
Affiliations

Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis

P J Brown et al. Bioorg Med Chem Lett. .

Abstract

Using solid-phase, parallel-array synthesis, a series of urea-substituted thioisobutyric acids was synthesized and assayed for activity on the human PPAR subtypes. GW7647 (3) was identified as a potent human PPARalpha agonist with approximately 200-fold selectivity over PPARgamma and PPARdelta, and potent lipid-lowering activity in animal models of dyslipidemia. GW7647 (3) will be a valuable chemical tool for studying the biology of PPARalpha in human cells and animal models of disease.

PubMed Disclaimer

MeSH terms

LinkOut - more resources