Interchromosomal effect leading to an increase in aneuploidy in sperm nuclei in a man heterozygous for pericentric inversion (inv 9) and C-heterochromatin
- PMID: 11355013
- DOI: 10.1007/s100380170073
Interchromosomal effect leading to an increase in aneuploidy in sperm nuclei in a man heterozygous for pericentric inversion (inv 9) and C-heterochromatin
Abstract
We describe a man with pericentric inversion 9 and constitutive heterochromatin, and a high disomy rate in his sperm cells (with all probes analyzed). The disomy rate was estimated with the following probes: 8, 9, 18, X, and Y, and was significantly higher than that in control sperm cells, while chromosome 9 showed the highest disomy frequency. The probes of X and Y together showed the same disomy frequency as X and Y alone, which indicates the same nondisjunction rate in the first meiotic division. We suggest that the interchromosomal effect found in this man differed from other findings in sperm cells of men carrying an inversion in terms of the difference in the length of the heterochromatin between the two chromosomes 9. Also, it is well known that the effect of inversion 9 with increased heterochromatin is highly variable and may even vary in members of the same family.
Similar articles
-
Sperm meiotic segregation and aneuploidy in a 46,X,inv(Y),t(10;15) carrier: case report.Fertil Steril. 2009 Nov;92(5):1748.e9-13. doi: 10.1016/j.fertnstert.2009.08.020. Epub 2009 Sep 4. Fertil Steril. 2009. PMID: 19733349
-
Mitotic disturbances associated with inversion 9qh. A case report.Ann Genet. 1990;33(3):169-72. Ann Genet. 1990. PMID: 2149631
-
Chromosome segregation in a man heterozygous for a pericentric inversion, inv(9)(p11q13), analyzed by using sperm karyotyping and two-color fluorescence in situ hybridization on sperm nuclei.Hum Genet. 1997 Jun;99(6):761-5. doi: 10.1007/s004390050444. Hum Genet. 1997. PMID: 9187669
-
Interchromosomal effect in sperm of males with translocations: report of 6 cases and review of the literature.Int J Androl. 2005 Dec;28(6):372-9. doi: 10.1111/j.1365-2605.2005.00571.x. Int J Androl. 2005. PMID: 16300670 Review.
-
Meiotic segregation analysis in spermatozoa of pericentric inversion carriers using fluorescence in-situ hybridization.Hum Reprod. 2007 Jan;22(1):136-41. doi: 10.1093/humrep/del317. Epub 2006 Aug 17. Hum Reprod. 2007. PMID: 16917123 Review.
Cited by
-
Infertility patients with chromosome inversions are not susceptible to an inter-chromosomal effect.J Assist Reprod Genet. 2019 Mar;36(3):509-516. doi: 10.1007/s10815-018-1376-1. Epub 2018 Dec 15. J Assist Reprod Genet. 2019. PMID: 30554392 Free PMC article.
-
Hereditary chromosomal 9 inversion (p22q13) 9 as a cause for recurrent pregnancy loss: a case report.J Med Case Rep. 2023 Oct 13;17(1):427. doi: 10.1186/s13256-023-04137-z. J Med Case Rep. 2023. PMID: 37828559 Free PMC article.
-
Chromosome heteromorphisms: do they entail a reproductive risk for male carriers?Asian J Androl. 2020 Sep-Oct;22(5):544-546. doi: 10.4103/aja.aja_130_19. Asian J Androl. 2020. PMID: 31929195 Free PMC article. No abstract available.
-
The Interchromosomal Effect: Different Meanings for Different Organisms.Genetics. 2020 Nov;216(3):621-631. doi: 10.1534/genetics.120.303656. Genetics. 2020. PMID: 33158985 Free PMC article. Review.
-
Chromosomal abnormalities in couples with recurrent spontaneous miscarriage: a 21-year retrospective study, a report of a novel insertion, and a literature review.J Assist Reprod Genet. 2019 Mar;36(3):499-507. doi: 10.1007/s10815-018-1373-4. Epub 2018 Nov 23. J Assist Reprod Genet. 2019. PMID: 30470960 Free PMC article.