[Study on the relationship between the history of abnormal pregnancy and TORCH infection in pregnant woman]

Abstract

Objective: To investigate the relationship between the history of abnormal pregnancy and the Toxoplasma(TOX), Other(OTH), Rubella virus(RUV), Cytomegalo virus(CMV), Herpes simplex virus-II (HSV-II) (TORCH) infections in pregnant woman.

Methods: Enzyme-Linked immunosorbent assay(ELISA) combined with polymerase chain reaction (PCR) technique were used to detect TORCH infection in pregnant women with histories of abnormal pregnancies(study group, n = 54) and normal pregnant women (control group, n = 54). The fetal cord blood samples were also detected.

Results: In study group, the rates of previous TORCH infection: CMV 46.29%, RUV 16.29%, TOX 16.67%, HSV-II 29.63%. The rates of active infection: CMV 57.40%, RUV 59.26%, TOX 38.89%, HSV-II 46.29%. The rates of recurrent infection: CMV 38.89%, RUV 38.89%, TOX 11.11%, HSV-II 22.22%. These three kinds of infection rates in study group were significantly higher than that of control group (P < 0.01). The abnormal pregnant cntcomes in study group were significantly higher than that of control group(P < 0.01). The incidence of maternal-fetal vertical transmission in study group was 73.08%.

Conclusion: TORCH series infection is one of the important causes of abnormal pregnant cutcomes. It is absolutely necessary to screen TORCH infection for women who had the histories of abnormal pregnancies in order to prevent birth defects and perinatal complications. ELISA combined with PCR technique is a valuable method for the diagnosis of TORCH infection.