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. 1997 Feb 21:(No 265):6.

ABT-378: Abbott "second generation" protease inhibitor

  • PMID: 11364243

ABT-378: Abbott "second generation" protease inhibitor

J S James. AIDS Treat News. .

Abstract

AIDS: Abbott Laboratories has released the first public data on ABT-378, a new generation protease inhibitor that is designed to be effective even against protease inhibitor-resistant HIV. ABT-378 is active against viruses that are resistant to ritonavir and indinavir. Early tests indicate that combining the drug with a fraction of the usual dose of ritonavir delays the body's destruction of the drug, and it may only require one or two daily doses. No human testing has been done.

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