Postexposure prophylaxis for HIV
- PMID: 11364478
Postexposure prophylaxis for HIV
Abstract
AIDS: Postexposure prophylaxis represents an advance in the management of percutaneous exposure to HIV in the workplace, but its efficacy in other settings needs further study. Three types of occupational exposure, percutaneous, mucous membrane, skin contact or loss of skin integrity, the postexposure prophylaxis to be used or offered, and the risk data and assessment for HIV acquisition are examined. Analysis of HIV transmission through percutaneous exposure reveals that occupational risk for health care workers is increased by deep injury to the exposed worker, visible blood on the injuring device, exposure of the device to source patients' vein or artery, and source patient's death from AIDS within 60 days of the accident. Prophylaxis for percutaneous exposure, if indicated, should be initiated within 1 to 2 hours to be effective. HIV antibody titers should be measured immediately and at 6 weeks, 12 weeks, and 6 months after exposure. AZT prophylaxis following percutaneous occupational exposure has dramatically decreased transmission in this setting and multiple drug regimens have become the standard of care to further increase efficacy. Sexual contact is the most frequent means of transmitting HIV infection and reducing exposure is the mainstay of public health efforts. Prophylaxis after non-occupational exposures such as sexual intercourse or sharing needles could potentially decrease transmission, although efficacy has not yet been demonstrated. Routine prophylaxis after sexual exposure may be an ineffective strategy.
Similar articles
-
[Post-exposure HIV prevention within and outside the hospital].Ther Umsch. 1998 May;55(5):289-94. Ther Umsch. 1998. PMID: 9643126 Review. German.
-
A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group.N Engl J Med. 1997 Nov 20;337(21):1485-90. doi: 10.1056/NEJM199711203372101. N Engl J Med. 1997. PMID: 9366579
-
Occupational exposure to HIV infection in health care workers.Med Sci Monit. 2003 May;9(5):CR197-200. Med Sci Monit. 2003. PMID: 12761457
-
[Occupational exposure to HIV in health care workers, Silesia voivodeship].Med Pr. 2010;61(3):315-22. Med Pr. 2010. PMID: 20677431 Polish.
-
[HIV occupational infections in gynecology: risk assessment, post-exposure management, and drug prophylaxis].Minerva Ginecol. 2000 Dec;52(12 Suppl 1):25-33. Minerva Ginecol. 2000. PMID: 11526686 Review. Italian.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical