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. 1998 Mar;10(3):17-9.

Advances in the virology of HIV infections and implications for clinical management

S Vella
  • PMID: 11365117

Advances in the virology of HIV infections and implications for clinical management

S Vella. AIDS Clin Care. 1998 Mar.

Abstract

AIDS: Recent advances have been made in basic science that have led to a better understanding of the mechanisms of HIV infection, particularly the dynamics and kinetics of in vivo viral replication and the emergence of drug resistance. Advances pertaining to HIV eradication, the virologic response to antiretroviral therapy, and resistance to antiretroviral drugs are reviewed. Clinical implications from these advances indicate that while the optimum time to initiate antiretroviral therapy is still uncertain, once begun, the therapy should be maximally suppressive to limit the potential of resistant variants. Also, a change to a salvage regimen should be considered when virus levels rise to values approaching 500 copies/ml. Strategies for long-term control of viral replication are currently being tested.

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