Abstract

AIDS: When seeking alternative therapies for treatment-experienced patients, several issues must be addressed. Considerations for various therapies include determining what is an acceptable level of viral load to be achieved, and how many drugs should be used in combination regimens. Clinical data supporting these approaches are detailed. To provide effective treatments for experienced patients, pharmaceutical companies should design drugs that differ considerably from current drugs, which are achieving positive results mainly in treatment-naive populations. A glossary of terms used in the article is provided.