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Review
. 2001 May 1;11(9):R367-70.
doi: 10.1016/s0960-9822(01)00196-8.

DNA replication: building the perfect switch

J F Diffley  1
Affiliations
Free article
Review

DNA replication: building the perfect switch

J F Diffley. Curr Biol. .
Free article

Abstract

A sophisticated molecular switch ensures that replication origins are activated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.

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