DNA replication: building the perfect switch
- PMID: 11369250
- DOI: 10.1016/s0960-9822(01)00196-8
DNA replication: building the perfect switch
Abstract
A sophisticated molecular switch ensures that replication origins are activated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.
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