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. 2000 Nov;10(8):338-45.
doi: 10.1016/s1050-1738(01)00071-8.

Intracellular assembly of VLDL: two major steps in separate cell compartments

S O Olofsson  1 , P Stillemark-Billton, L Asp
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Intracellular assembly of VLDL: two major steps in separate cell compartments

S O Olofsson et al. Trends Cardiovasc Med. 2000 Nov.

Abstract

The assembly of very low-density lipoproteins (VLDL) occurs in two major steps. The first step is the co-and post-translational lipidation of apoB, forming pre-VLDL in the rough endoplasmic reticulum. The microsomal triglyceride transfer protein catalyzes this step. In the second step pre-VLDL is converted to bona fide VLDL in a smooth membrane compartment. This step depends on ADP-ribosylation factor 1 and its activation of phospholipase D.

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