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Comment
. 2001 May 21;193(10):F35-9.
doi: 10.1084/jem.193.10.f35.

CD8 T cell detection of bacterial infection: sniffing for formyl peptides derived from Mycobacterium tuberculosis

G Lauvau  1 , E G Pamer
Affiliations
Comment

CD8 T cell detection of bacterial infection: sniffing for formyl peptides derived from Mycobacterium tuberculosis

G Lauvau et al. J Exp Med. .
No abstract available

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Figures

Figure 1
Figure 1
H2-M3 mobilization upon bacterial infection. Under normal circumstances (top panel), endogenous self-peptides (closed blue symbols) are generated in the cytosol and presented by classical MHC class Ia molecules. In contrast, empty class Ib molecules (H2-M3) are mostly retained in the ER, while a few mitochondrial formylated peptides are bound and presented by H2-M3 at the cell surface. After bacterial infection (bottom panel), empty ER-resident H2-M3 molecules are rapidly loaded with bacterially secreted formylated peptides (open red symbols) and form the majority of H2-M3 complexes on the cell surface. By contrast, peptides derived from bacterial antigens (closed red symbols) that are presented by MHC class Ia molecules are rare when compared with self-derived peptides.
See this image and copyright information in PMC

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