[The characteristics diagnosis and treatment of hepatic metastasis of simple immature ovarian teratoma]

Abstract

Objective: To analyze the characteristics of hepatic metastasis of pure immature ovarian teratoma and explore proper diagnosis and treatment.

Methods: A total of 18 cases with hepatic metastasis of pure immature ovarian teratoma were involved in this study. The clinical stage, operation, chemotherapy and histopathology of primary and secondary tumor as well as the data of long term follow-up were analyzed retrospectively.

Results: All of the hepatic metastatic tumor located on the surface of liver, 66.1% (11/18) of them was clinically stage 3 and 44.4% (8/18) was grade 1 at first operation. The hepatic metastatic rate was 16.7% (3/18) in standard adjuvant chemotherapy group but increased obviously to 31.2% (15/48) in irregular chemotherapy group. Auxiliary diagnostic methods could not indicate correct results. The surgical resection rate of hepatic metastasis of pure immature ovarian teratoma was 94.4% (17/18). There was less complication occurred in the group with the diameter of tumor less than 15 cm. The follow-up time ranged from 3-205 months with the mean of 20.9 months. The 3 year survival rate was 77.8% (14/18), lost of follow-up rate was 0.0% (0/18); The 5 year and 10 year survival rate was 55.6% (10/18) and 38.9% (7/18) respectively, lost of follow-up rate was 22.2% (4/18) and 38.9% (7/18) respectively, one of them had survived for more than 17 years.

Conclusions: The hepatic metastatic rate of pure immature ovarian teratoma could be decreased by using standard adjuvant chemotherapy. Suitable surgical treatment could reduce complication and improve the prognosis of this kind of patients.