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. 1975 Mar;7(3):298-305.
doi: 10.1128/AAC.7.3.298.

BL-S 640, a cephalosporin with a broad spectrum of antibacterial activity: properties in vitro

F Leitner, R E Buck, M Misiek, T A Pursiano, K E Price

BL-S 640, a cephalosporin with a broad spectrum of antibacterial activity: properties in vitro

F Leitner et al. Antimicrob Agents Chemother. 1975 Mar.

Abstract

BL-S 640 was evaluated in vitro by comparison with cephalothin, cephaloridine, cefazolin, and cephalexin. The new compound was more active than the control cephalosporins against most major gram-negative and some gram-positive species. Moreover, its antibacterial spectrum included strains of Enterobacter, Proteus morganii, P. rettgeri, and Providencia stuartii, species generally resistant to the other cephalosporins. BL-S 640 was an effective bactericidal agent for strains of various species of Enterobacteriaceae. In human plasma, the compound was 58% protein bound.

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