[Murine models for human diseases]

Abstract

This article is a bibliographic review concerning mouse mutations, spontaneous, induced or genetically engineered, as models of human genetic diseases. Since the beginning of the last century, mouse models have been instrumental in the understanding of the pathogenesis of many diseases and designing of new therapies. A number of recent technological advances in embryo manipulation and many large-scale mutagenesis screens will dramatically increase the availability of new mouse models in the near future. In the "post-genomic" era, mouse mutants will have a significant role as a model system for functional genome analysis of the upcoming whole-genome information of the human and mouse genomes projects.