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. 2001 Mar;258(3):101-5.
doi: 10.1007/s004050100315.

Immunohistochemical study on proliferative activity of experimental cholesteatoma

K Park  1 , H J Park, Y M Chun
Affiliations

Immunohistochemical study on proliferative activity of experimental cholesteatoma

K Park et al. Eur Arch Otorhinolaryngol. 2001 Mar.

Abstract

In this study, we induced canal ligation cholesteatoma using Mongolian gerbils and investigated the hyperproliferative nature of canal ligation cholesteatoma by using an immunohistochemical technique with proliferation markers (cytokeratin 13/16, PCNA, EGFR, thrombomodulin). Canal ligation cholesteatoma using Mongolian gerbils had a hyperproliferative character in the suprabasal cell layer similar to human cholesteatomas. This result will provide a good morphological basis for future cholesteatoma animal research concerning the pathogenesis of cholesteatoma.

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