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Review
. 2001 May;3(6):475-9.
doi: 10.1016/s1286-4579(01)01403-4.

Neuropathogenesis of influenza virus infection in mice

I Mori  1 , Y Kimura
Affiliations
Free article
Review

Neuropathogenesis of influenza virus infection in mice

I Mori et al. Microbes Infect. 2001 May.
Free article

Abstract

The neurovirulent WSN strain of influenza A virus, introduced into the olfactory bulb of C57BL/6 mice, selectively attacks several brain nuclei which are highly implicated in the pathogenesis of neuropsychiatric disturbances. The virus-infected neurons are eradicated through apoptotic neurodegeneration. On the other hand, activated microglia serve the neuroprotection against virus infection.

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