Review
doi: 10.1016/s1286-4579(01)01403-4.
Neuropathogenesis of influenza virus infection in mice
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- PMID: 11377209
- DOI: 10.1016/s1286-4579(01)01403-4
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Review
Neuropathogenesis of influenza virus infection in mice
Microbes Infect.
2001 May.
Free article
Abstract
The neurovirulent WSN strain of influenza A virus, introduced into the olfactory bulb of C57BL/6 mice, selectively attacks several brain nuclei which are highly implicated in the pathogenesis of neuropsychiatric disturbances. The virus-infected neurons are eradicated through apoptotic neurodegeneration. On the other hand, activated microglia serve the neuroprotection against virus infection.
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