Review
doi: 10.1016/s1286-4579(01)01405-8.
Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells
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- PMID: 11377211
- DOI: 10.1016/s1286-4579(01)01405-8
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Review
Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells
Microbes Infect.
2001 May.
Free article
Abstract
Shigella dysenteriae and Shiga-toxin-producing Escherichia coli (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome. This review provides an overview of the mechanisms of action of Stx and a model of the pathogenesis of Stx-induced disease.
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