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Review
. 2001 Jun;11(3):274-8.
doi: 10.1016/s0959-437x(00)00190-8.

Of flies and men--studying human disease in Drosophila

A Bernards  1 , I K Hariharan
Affiliations
Review

Of flies and men--studying human disease in Drosophila

A Bernards et al. Curr Opin Genet Dev. 2001 Jun.

Abstract

During the past year, the Drosophila genome has been sequenced. More than 60% of genes implicated in human disease have Drosophila orthologues. Developments in RNA-mediated interference and homologous recombination have made 'reverse genetics' feasible in Drosophila. Conventional Drosophila genetics is being used increasingly to place human disease genes of unknown function in the context of functional pathways.

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