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Review
. 2001 Jun;11(3):287-92.
doi: 10.1016/s0959-437x(00)00192-1.

Insulin/IGF signalling and ageing: seeing the bigger picture

D Gems  1 , L Partridge
Affiliations
Review

Insulin/IGF signalling and ageing: seeing the bigger picture

D Gems et al. Curr Opin Genet Dev. 2001 Jun.

Abstract

Although the underlying mechanisms of ageing are not understood, it is known that the longevity of the nematode Caenorhabditis elegans is modulated by an insulin/IGF-signalling pathway. The focus now is on how this pathway is regulated, how it controls nematode ageing, and how this relates to the ageing process in higher animals.

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