Review
doi: 10.1016/s1369-5274(00)00202-2.
Host-pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes
Affiliations
- PMID: 11378478
- DOI: 10.1016/s1369-5274(00)00202-2
Item in Clipboard
Review
Host-pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes
Curr Opin Microbiol.
2001 Jun.
Abstract
Recent studies have confirmed the infectious and inflammatory nature of arthritis induced by Borrelia burgdorferi, or Lyme arthritis. This arthritis is directed by the presence of the bacteria in joint tissue, and is mediated through activation of the Toll-like receptor 2 (TLR2) signaling pathways by borrelial lipoproteins. Several host genes regulate the severity of arthritis, possibly by regulating the balance of pro- and anti-inflammatory responses.
Similar articles
-
Interleukin-4 (IL-4) and IL-13 signaling pathways do not regulate Borrelia burgdorferi-induced arthritis in mice: IgG1 is not required for host control of tissue spirochetes.Infect Immun. 2000 Oct;68(10):5603-9. doi: 10.1128/IAI.68.10.5603-5609.2000. Infect Immun. 2000. PMID: 10992460 Free PMC article.
-
Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis.J Autoimmun. 2001 May;16(3):263-8. doi: 10.1006/jaut.2000.0495. J Autoimmun. 2001. PMID: 11334491 Review.
-
Host-pathogen interactions and the pathogenesis of murine Lyme disease.Curr Opin Rheumatol. 2002 Jul;14(4):399-403. doi: 10.1097/00002281-200207000-00011. Curr Opin Rheumatol. 2002. PMID: 12118174 Review.
-
Infectious arthritis and immune dysregulation: lessons from Lyme disease.Curr Opin Rheumatol. 2010 Jul;22(4):451-5. doi: 10.1097/BOR.0b013e328338f73f. Curr Opin Rheumatol. 2010. PMID: 20375899 Review.
-
Pathogenesis of Lyme disease.Rheumatol Int. 1989;9(3-5):233-5. doi: 10.1007/BF00271887. Rheumatol Int. 1989. PMID: 2692132 Review.
Cited by
-
Borrelia burgdorferi elicited-IL-10 suppresses the production of inflammatory mediators, phagocytosis, and expression of co-stimulatory receptors by murine macrophages and/or dendritic cells.PLoS One. 2013 Dec 19;8(12):e84980. doi: 10.1371/journal.pone.0084980. eCollection 2013. PLoS One. 2013. PMID: 24367705 Free PMC article.
-
Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages.Infect Immun. 2015 Dec;83(12):4848-60. doi: 10.1128/IAI.01215-15. Epub 2015 Oct 5. Infect Immun. 2015. PMID: 26438793 Free PMC article.
-
Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi.Infect Immun. 2002 Mar;70(3):1372-81. doi: 10.1128/IAI.70.3.1372-1381.2002. Infect Immun. 2002. PMID: 11854223 Free PMC article.
-
Viable Borrelia burgdorferi enhances interleukin-10 production and suppresses activation of murine macrophages.Infect Immun. 2008 Mar;76(3):1153-62. doi: 10.1128/IAI.01404-07. Epub 2007 Dec 17. Infect Immun. 2008. PMID: 18086805 Free PMC article.
-
Inhibition of HDAC6 protects against rhabdomyolysis-induced acute kidney injury.Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F502-F515. doi: 10.1152/ajprenal.00546.2016. Epub 2017 Jan 4. Am J Physiol Renal Physiol. 2017. PMID: 28052874 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
