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Clinical Trial
. 1979 Jun 21;63(3):199-202.
doi: 10.1007/BF00433549.

Zimelidine: a therapeutic and pharmacokinetic study in depression

A Coppen, V A Ramo Rao, C Swade, K Wood
Clinical Trial

Zimelidine: a therapeutic and pharmacokinetic study in depression

A Coppen et al. Psychopharmacology (Berl). .

Abstract

Zimelidine, a bicyclic compound with a strong effect on the neuronal reuptake of 5-hydroxy-tryptamine and with weak anticholinergic actions, was evaluated for its antidepressant efficacy in a double-blind comparative trial with amitriptyline. In doses of 200 mg a day it was found to be as effective as 150 mg amitriptyline, but with significantly less subjective side-effects. The plasma concentration of zimelidine and its metabolite, norzimelidine, showed no significant correlation with therapeutic outcome.

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References

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