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Review
. 2001 May 28;153(5):F19-24.
doi: 10.1083/jcb.153.5.f19.

PDZ protein interactions regulating glutamate receptor function and plasticity

S Tomita  1 , R A Nicoll, D S Bredt
Affiliations
Review

PDZ protein interactions regulating glutamate receptor function and plasticity

S Tomita et al. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
Differential regulation of synaptic glutamate receptors by PDZ proteins. NH2-terminal palmitoylation anchors PSD-95 at the postsynaptic density, and PDZ domains from PSD-95 associate with the COOH termini of NMDA receptor subunits. By contrast, AMPA receptor delivery to the plasma membrane requires stargazin. Synaptic targeting of AMPA receptors requires stargazin binding to PDZ proteins such as SAP-97, which additionally binds the COOH terminus of the GluR1 subunit of AMPA receptors. Whereas NMDA receptors are firmly anchored at the postsynaptic membrane, synaptic expression of AMPA receptors is dynamically regulated by neuronal activity. During intense synaptic stimulation, calcium influx through NMDA receptors activates CaMKII, which mediates insertion of synaptic AMPA receptors.
Figure 2
Figure 2
Tetraspanin–MAGUK complexes regulate both synapses and tight junctions. At neuronal synapses, the tetraspanin, stargazin associates with AMPA receptors and interacts with PDZ domains from neuronal MAGUKs. At tight junctions, a related protein complex is formed between claudin and epithelial cell MAGUKs, which also bind to occludin. Extracellular interactions of claudin proteins bridge cells at tight junctions, and can regulate paracellular flux of Mg2+. Whether stargazin participates in analogous transsynaptic interactions is uncertain.
See this image and copyright information in PMC

References

    1. Beattie E.C., Carroll R.C., Yu X., Morishita W., Yasuda H., von Zastrow M., Malenka R.C. Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat. Neurosci. 2000;3:1291–1300. - PubMed
    1. Brenman J.E., Chao D.S., Gee S.H., McGee A.W., Craven S.E., Santillano D.R., Huang F., Xia H., Peters M.F., Froehner S.C. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α-1 syntrophin mediated by PDZ motifs. Cell. 1996;84:757–767. - PubMed
    1. Brenman J.E., Topinka J.R., Cooper E.C., McGee A.W., Rosen J., Milroy T., Ralston H.J., Bredt D.S. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. J. Neurosci. 1998;18:8805–8813. - PMC - PubMed
    1. Chen L., Bao S., Qiao X., Thompson R.F. Impaired cerebellar synapse maturation in waggler, a mutant mouse with a disrupted neuronal calcium channel gamma subunit. Proc. Natl. Acad. Sci. USA. 1999;96:12132–12137. - PMC - PubMed
    1. Chen L., Chetkovich D.M., Petrailia R.S., Sweeney N.T., Kawaski Y., Wenthold R.J., Bredt D.S., Nicoll R.A. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature. 2000;408:936–943. - PubMed

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