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. 2001 Jun;28(2):126-8.
doi: 10.1038/88836.

Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

P Sklar  1 , S G Schwab, N M Williams, M Daly, S Schaffner, W Maier, M Albus, M Trixler, P Eichhammer, B Lerer, J Hallmayer, N Norton, H Williams, S Zammit, A G Cardno, S Jones, G McCarthy, V Milanova, G Kirov, M C O'Donovan, E S Lander, M J Owen, D B Wildenauer
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Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

P Sklar et al. Nat Genet. 2001 Jun.

Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

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