Interactions between motor activity and sterotypy in cocaine-treated rats

Abstract

Effect of a single administration of a dose (5, 10, or 15 mg/kg, i.p.) of cocaine hydrochloride on spontaneous motor activity (SMA) and stereotypy (ST), and interactions between these behaviors were investigated in rats. SMA showed peak increases within 10 min and at 120 min after cocaine injection. Drug-induced stereotypy was maximal during the interval between these two peaks in SMA. Several neurotransmitters may be involved in the interactions between SMA and ST.