doi: 10.1093/nar/2.4.459.
A proton magnetic resonance investigation of the glycosyl torsion angle of uracil nucleosides and nucleotides
- PMID: 1138232
- PMCID: PMC342854
- DOI: 10.1093/nar/2.4.459
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A proton magnetic resonance investigation of the glycosyl torsion angle of uracil nucleosides and nucleotides
Nucleic Acids Res.
1975 Apr.
Free PMC article
Abstract
The use of line-shape decomposition techniques permitted the small 5-bond (5-J51') and 4-bond (4-J61') proton-proton coupling constants of a series of uracil nucleosides and nucleotides to be determined accurately. From an analysis of these coupling constants we have determined that the uracil base is in a predominantly anti conformation in aqueous solution and the mean position is not substantially altered by phosphate substitution at the 2', 3', or 5' positions, by changing the furanose stereochemistry from a ribose to a deoxyribose or an arabinose, or by an increase in temperature of 43 degree C.
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