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Review
. 2001 Apr;10(2):383-92, x.

The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis

W G Stetler-Stevenson  1
Affiliations
  • PMID: 11382593
Review

The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis

W G Stetler-Stevenson. Surg Oncol Clin N Am. 2001 Apr.

Abstract

Tumor invasion and metastasis formation are the hallmarks of malignant cancer. Metastatic spread of cancer cells is a result of a complex cascade of cellular events. This article discusses the matrix metalloproteinase family, the regulation of matrix metalloproteinase activity, and the functions of matrix metalloproteinases in tumor progression.

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