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. 1979 Jun 28;64(1):81-3.
doi: 10.1007/BF00427349.

The action of DL-2,4-diaminobutyric acid on the cataleptogenic effects of pilocarpine and alpha-flupenthixol in rats

J Williams, J A Davies

The action of DL-2,4-diaminobutyric acid on the cataleptogenic effects of pilocarpine and alpha-flupenthixol in rats

J Williams et al. Psychopharmacology (Berl). .

Abstract

The existence of a strionigral GABA-ergic pathway having an inhibitory effect on the nigrostriatal dopaminergic system has been proposed. The work reported in this paper was undertaken to investigate whether modification of the GABA-eric system by the GABA neuronal uptake inhibitor DL-2,4-diaminobutyric acid (DABA) would affect cholinergic (pilocarpine) and/or neuroleptic alpha-flupenthixol (alpha-FPT) induced catalepsy. DABA pretreatment was shown to enhance significantly both alpha-FPT and pilocarpine induced catalepsy. DABA alone had no cataleptic activity. The results are interpreted as supporting the existence of an inhibitory strionigral GABA-ergic pathway.

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