Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001 Apr;24(4):274-87.
doi: 10.1007/BF03343858.

Enhancing insulin action: from chemical elements to thiazolidinediones

R Perfetti  1 , K Chamie
Affiliations
Review

Enhancing insulin action: from chemical elements to thiazolidinediones

R Perfetti et al. J Endocrinol Invest. 2001 Apr.

Abstract

Type 2 diabetes is characterized by two fundamental biological defects: a reduced glucose-dependent insulin secretion and an increased resistance to the action of insulin at the level of various target tissues. While the use of agents to improve the insulin secretory activity of the islets of Langerhans has witnessed the flourishing of several new drugs over the years, a much greater difficulty has been experienced in the search for insulin-sensitizing drugs. The aim of this article is to critically review this topic, and to emphasize the importance of providing alternative strategies for the management of Type 2 diabetes.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Drugs. 1999 Jun;57(6):921-30; discussion 931-2 - PubMed
    1. Nihon Jinzo Gakkai Shi. 1992 Feb;34(2):125-32 - PubMed
    1. Biochemistry. 1995 May 9;34(18):6218-25 - PubMed
    1. Methods Enzymol. 1991;196:428-42 - PubMed
    1. J Biol Chem. 2000 Jun 2;275(22):16690-6 - PubMed

LinkOut - more resources