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. 1979 Jun 28;64(1):95-7.
doi: 10.1007/BF00427352.

Urinary 4-hydroxy-3-methoxyphenylglycol is not a predictor for clinical response to amitriptyline in depressive illness

A Coppen, V A Rama Rao, C R Ruthven, B L Goodwin, M Sandler

Urinary 4-hydroxy-3-methoxyphenylglycol is not a predictor for clinical response to amitriptyline in depressive illness

A Coppen et al. Psychopharmacology (Berl). .

Abstract

The urinary excretion of 4-hydroxy-3-methoxyphenylglycol was compared in a group of 23 depressive patients and 27 control subjects of similar age. There was no difference between patients and controls although female controls excreted less than males. After 6 weeks' treatment with 150 mg daily of amitriptyline there was no correlation between therapeutic response and pretreatment urinary excretion value.

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