Expanding drug resistance through integron acquisition by IncFI plasmids of Salmonella enterica Typhimurium
- PMID: 11384524
- PMCID: PMC2631783
- DOI: 10.3201/eid0703.010314
Expanding drug resistance through integron acquisition by IncFI plasmids of Salmonella enterica Typhimurium
Abstract
We conducted a 30-year retrospective analysis of IncFI plasmids from Salmonella enterica serotype Typhimurium. These plasmids have been associated with the emergence of epidemic clones of multidrug-resistant Salmonella. Molecular and genetic evidence indicates that IncFI plasmids are evolving through sequential acquisition of integrons carrying different arrays of antibiotic- resistance genes.
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