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Review

. 2001 May;94(5):221-5.

doi: 10.1177/014107680109400506.

The renal tubular acidoses

R J Unwin¹, G Capasso

Affiliations

PMID: 11385088
PMCID: PMC1281453
DOI: 10.1177/014107680109400506

Review

The renal tubular acidoses

R J Unwin et al. J R Soc Med. 2001 May.

. 2001 May;94(5):221-5.

doi: 10.1177/014107680109400506.

Authors

R J Unwin¹, G Capasso

Affiliation

¹ Centre for Nephrology, Royal Free and University College Medical School, University College London, UK. robert.unwin@ucl.ac.uk

PMID: 11385088
PMCID: PMC1281453
DOI: 10.1177/014107680109400506

No abstract available

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Figures

<i>Figure 1</i> — Figure 1
Main sites of H⁺ secretion

<i>Figure 2</i> — Figure 2
Current cellular models of tubule acidification (proximal versus distal). CA=carbonic anhydrase; PC=principal cell; α-IC=intercalated cell; p.d.=potential difference

<i>Figure 3</i> — Figure 3
Acid-base renal tubular cell membrane transporters

<i>Figure 4</i> — Figure 4
Urine pH versus plasma bicarbonate in renal tubular acidosis (RTA) (adapted from Refs and 31)

See this image and copyright information in PMC

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References

1. Madias NE, Kraut JA. Uremic acidosis. In Seldin DW, Giebisch G, eds. The Regulation of Acid—Base Balance. New York: Raven Press, 1989: 285-317
1. Kamel KS, Briceno LF, Sanchez MI, et al. A new classification for renal defects in net acid excretion. Am J Kidney Dis 1997;29: 136-46 - PubMed
1. Boron WF. Chemistry of buffer equilibria in blood plasma. In Seldin DW, Giebisch G, eds. The Regulation of Acid-Base Balance. New York: Raven Press, 1989: 3-32
1. DuBose TDJ. Hyperkalemic metabolic acidosis. Am J Kidney Dis 1999;33: XLV-XLVIII - PubMed
1. Alpern RJ. Cell mechanisms of proximal tubule acidification. Physiol Rev 1990;70: 79-114 - PubMed

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