Review
doi: 10.1186/gb-2001-2-5-reviews1015.
Epub 2001 Apr 26.
Morpholino antisense oligonucleotides: tools for investigating vertebrate development
Affiliations
- PMID: 11387041
- PMCID: PMC138935
- DOI: 10.1186/gb-2001-2-5-reviews1015
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Review
Morpholino antisense oligonucleotides: tools for investigating vertebrate development
Genome Biol.
2001.
Abstract
Antisense oligonucleotides provide a promising approach to investigating gene function in vivo, but their ability to offer unambiguous insights into phenotypes has been debated. The recent use of morpholino antisense oligonucleotides in zebrafish embryos may prove a major advance, but rigorous controls are essential.
Figures
Structures of DNA and morpholino oligonucleotides. R and R' denote continuation of the oligomer chain in the 5' or 3' direction, respectively.
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