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Review
. 2001 Jun;6(3):199-205.
doi: 10.1023/a:1011388710719.

IGFBP-3 and apoptosis--a license to kill?

A J Butt  1 , A C Williams
Affiliations
Review

IGFBP-3 and apoptosis--a license to kill?

A J Butt et al. Apoptosis. 2001 Jun.

Abstract

Insulin-like growth factor binding protein (IGFBP)-3, the major carrier of insulin-like growth factors (IGFs) in the circulation, was first isolated and characterised over a decade ago. More recently, IGFBP-3 has been assigned a role as a putative death-promoting factor, a function that appears, under certain circumstances, to be independent of its IGF-binding ability. This review examines the current evidence for a pro-apoptotic function for IGFBP-3 and speculates on its physiological significance.

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