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. 2001 May;40(5):249-52.
doi: 10.1177/000992280104000502.

Frequency of celiac disease in individuals with Down syndrome in the United States

J Mackey  1 , W R Treem, G Worley, A Boney, P Hart, P S Kishnani
Affiliations

Frequency of celiac disease in individuals with Down syndrome in the United States

J Mackey et al. Clin Pediatr (Phila). 2001 May.

Abstract

Ninety-three individuals with Down syndrome (DS) were screened to investigate the prevalence of celiac disease (CD) in the United States. Five of the 93 individuals were antiendomysial antibody (EMA) positive. Of the 5 who tested positive for EMA, 4 were biopsied, 1 refused biopsy. Three of the 4 individuals biopsied manifested changes of CD on small bowel biopsy. This gives a frequency of 3.2% of confirmed CD in our DS individuals and suggests the need for periodic screening for celiac disease in this population.

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