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. 2001 Jun;3(6):567-72.
doi: 10.1038/35078543.

Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells

S X Lin  1 , B Grant, D Hirsh, F R Maxfield
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Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells

S X Lin et al. Nat Cell Biol. 2001 Jun.

Abstract

RME-1 is an Eps15-homology (EH)-domain protein that was identified in a genetic screen for endocytosis genes in Caenorhabditis elegans. When expressed in a CHO cell line, the worm RME-1 protein and a mouse homologue are both associated with the endocytic recycling compartment. Here we show that expression of a dominant-negative construct with a point mutation near the EH domain results in redistribution of the endocytic recycling compartment and slowing down of transferrin receptor recycling. The delivery of a TGN38 chimaeric protein to the trans-Golgi network is also slowed down. The function of Rme-1 in endocytic recycling is evolutionarily conserved in metazoans as shown by the protein's properties in C. elegans.

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